Ozzy & Drix

Phil LaMarr

Osmosis Jones (voice)

Jeff Bennett

Drix (voice)

Alanna Ubach

Mayor Paul Spryman / Hector's Mom (voice)

Justin Cowden

Hector Cruz (voice)

Tasia Valenza

Maria Amino (voice)

Jim Cummings

Police Chief Gluteus (voice)

Rob Paulsen

Travis Lum (voice)

Vivica A. Fox

Ellen Patella (voice)

Pat Fraley

Brain Advisor #1 (voice)

Frank Welker

Dander (voice)

Jeffrey Tambor

The Mole (voice)

Charlie Adler

General Malaise (voice)

Kimberly Brooks

Christine Kolchuck (voice)

Kevin Michael Richardson

Rescue Cell (voice)

Cree Summer

Mayor Santorini (voice)

Tim Curry

Nick O'Teen (voice)

Tara Strong

Jenna (voice)

Brad Garrett

Strepfinger (voice)

Dawnn Lewis

Cilia Tyson (voice)

Joe Lala

Hector's Dad (voice)

Jim Belushi

Captain Quinine (voice)

Kath Soucie

Naurine / Celly Katz (voice)

Andrea Martin

Aunti Histamine (voice)

Candi Milo

Mumsy Glop (voice)