Big Mouth

Nick Kroll

Nick Birch / Maury the Hormone Monster / Coach Steve / Lola Skumpy / Rick the Hormone Monster (voice)

John Mulaney

Andrew Glouberman (voice)

Jessi Klein

Jessi Glaser (voice)

Jason Mantzoukas

Jay Bilzerian (voice)

Maya Rudolph

Diane Birch / Connie the Hormone Monstress (voice)

Fred Armisen

Elliot Birch (voice)

Jordan Peele

Ghost of Duke Ellington (voice)

Andrew Rannells

Matthew (voice)

Jenny Slate

Missy Foreman-Greenwald (voice)

Joe Wengert

Ayo Edebiri

Missy Foreman-Greenwald (voice)

June Diane Raphael

Devin (voice)

Richard Kind

Marty Glouberman (voice)

Jessica Chaffin

Shannon Glaser (voice)

Neil Casey

Lars (voice)

Paula Pell

Barbara Glouberman (voice)

Jon Daly

Judd Birch (voice)

Jak Knight

DeVon (voice)

Chelsea Peretti

Monica Foreman-Greenwald (voice)

Seth Morris

Greg Glaser (voice)

Gil Ozeri

Mark Rivers

Nathan Fillion

Nathan Fillion (voice)

Kat Dennings

Leah Birch (voice)