Rubberhead

Sarah Silverman

Self

Nathan Barnatt

Homeless Man (segment "Lisa")

Lauren Lapkus

Girl 5 (segment "Lisa")

John C. Reilly

Father (segment "Ham")

Laura Silverman

Self (segment "Knickers")

Seth Rogen

Officer Durand (segment "Knickers")

Jade Catta-Preta

Mother (segment "Lisa")

Natasha Leggero

Girl 2 (segment "Lisa")

Shelby Fero

Girl 1 (segment "Lisa")

Nathan Fielder

Self (segment "Retro Video Arcade")

David Dineen-Porter

Self (segment "Retro Video Arcade")

Kyle Dunnigan

Self

Michael Daniel Cassady

Self (segment "Lisa")

Brett Gelman

Self

Emily Maya Mills

Girl 6 (segment "Lisa")

Nick Rutherford

Father (segment "Lisa")

Rob Schrab

Self

Paul Rust

Self (segment "Lisa")

Stoney Sharp

Self

Armen Weitzman

Mailman

Kulap Vilaysack

Girl 3 (segment "Lisa")

Eric Wareheim

Self

Harris Wittels

Scientist 1 (segment "CCDF")

Lo Mutuc

Self